Hydrochloric Acid → HCID 86692581, compound

Participants

Reaction Steps

3N Hydrochloric acid aqueous solution (12 ml) was added at room temperature to a solution of N-[6-(8-fluoro-1,4-dioxaspiro[4.5]dec-8-yl)pyridin-3-yl]-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide (308 mg) described in Example K65 in tetrahydrofuran (12 ml), and stirred at the same temperature for six hours. After the reaction, a saturated aqueous solution of sodium bicarbonate was added, the solvent was evaporated, water was added and the precipitated solid was filtered to give the titled compound (257 mg) as a white solid.

Provenance & Evidence