Hydrochloric Acid → HCID 86692581, compound

HRID 1748641Notes

Reaction equation

HRID 1748641 reaction equation
Cl.[F:2][C:3]1([C:13]2[N:18]=[CH:17][C:16]([NH:19][C:20]([C:22]3[CH:23]=[N:24][N:25]([C:28]4[CH:33]=[CH:32][C:31]([C:34]([F:37])([F:36])[F:35])=[CH:30][N:29]=4)[C:26]=3[CH3:27])=[O:21])=[CH:15][CH:14]=2)CCC2(OCCO2)CC1.C(=O)(O)[O-].[Na+].[O:43]1[CH2:47][CH2:46][CH2:45][CH2:44]1>>[F:2][C:3]1([C:13]2[N:18]=[CH:17][C:16]([NH:19][C:20]([C:22]3[CH:23]=[N:24][N:25]([C:28]4[CH:33]=[CH:32][C:31]([C:34]([F:36])([F:35])[F:37])=[CH:30][N:29]=4)[C:26]=3[CH3:27])=[O:21])=[CH:15][CH:14]=2)[CH2:46][CH2:47][O:43][CH2:44][CH2:45]1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 516892Sodium BicarbonateHCID 86692582HCID 86692582, compound

Product 1

HCID 86692581HCID 86692581, compound

Procedure

3N Hydrochloric acid aqueous solution (12 ml) was added at room temperature to a solution of N-[6-(8-fluoro-1,4-dioxaspiro[4.5]dec-8-yl)pyridin-3-yl]-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide (308 mg) described in Example K65 in tetrahydrofuran (12 ml), and stirred at the same temperature for six hours. After the reaction, a saturated aqueous solution of sodium bicarbonate was added, the solvent was evaporated, water was added and the precipitated solid was filtered to give the titled compound (257 mg) as a white solid.

Workup

  1. customAfter the reaction
  2. customthe solvent was evaporated
  3. additionwater was added
  4. filtrationthe precipitated solid was filtered

Sources & evidence

ORD record
ord-0ca122aa45934ee1b1f2c0f83c4017cc
Source dataset
uspto-grants-2015_10
Patent number
US09150555B2

Reaction notes

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