HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1748692Generated: October 25, 2026
Water → 5-methyl-N-[6-(8-methyl-1,4-dioxaspiro[4.5]dec-8-yl)pyridin-3-yl]-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide
https://huagongshe.com/reaction/1748692
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | [6-(8-Methyl-1,4-dioxaspiro[4.5]dec-8-yl)pyridin-3-yl]amine | HCID 86692644 | — |
| Reactant | 5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxylic acid chloride | HCID 89734997 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 5-methyl-N-[6-(8-methyl-1,4-dioxaspiro[4.5]dec-8-yl)pyridin-3-yl]-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide | HCID 86692643 | 90% |
Reaction Steps
[6-(8-Methyl-1,4-dioxaspiro[4.5]dec-8-yl)pyridin-3-yl]amine (340 mg) was added to a solution of 5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxylic acid chloride (491 mg) described in Reference Example 180 in pyridine (7.0 ml) and stirred at 50° C. for an hour. After completion of the reaction, triethylamine (1.5 ml) and water was added and the precipitated solid was collected by filtration to give 5-methyl-N-[6-(8-methyl-1,4-dioxaspiro[4.5]dec-8-yl)pyridin-3-yl]-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide (618 mg) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09150555B2 |
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| Source dataset | uspto-grants-2015_10 |
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| ORD ID | ord-7de6985ebe1d49b796e7828e35fcfacb |
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| Source note | uspto-grants-2015_10 |
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