Potassium Carbonate → HCID 136216272, compound

HRID 1748725Notes

Reaction equation

HRID 1748725 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([OH:25])[CH:5]=[CH:6][C:7]=1[CH:8]1[S:14][CH2:13][CH2:12][NH:11][C:10]2[N:15]([CH3:24])[N:16]=[C:17]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=3)[C:9]1=2.C(=O)([O-])[O-].[K+].[K+].Cl.[CH3:33][C:34]1[C:39]([CH2:40]Cl)=[CH:38][CH:37]=[CH:36][N:35]=1>C(#N)C>[CH3:24][N:15]1[C:10]2[NH:11][CH2:12][CH2:13][S:14][CH:8]([C:7]3[CH:6]=[CH:5][C:4]([O:25][CH2:40][C:39]4[C:34]([CH3:33])=[N:35][CH:36]=[CH:37][CH:38]=4)=[CH:3][C:2]=3[CH3:1])[C:9]=2[C:17]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=2)=[N:16]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 122437123-(CHLOROMETHYL)-2-METHYLPYRIDINE HYDROCHLORIDEHCID 136216238HCID 136216238, compound

Product 1

HCID 136216272HCID 136216272, compoundYield 55%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
60 °C

Procedure

A mixture of 3-methyl-4-[1-methyl-3-(2-pyridyl)-4,6,7,8-tetrahydropyrazolo[3,4-e][1,4]thiazepin-4-yl]phenol (0.078 g, 0.22 mmol, see Ex. #D.42), potassium carbonate (0.061 g, 0.44 mmol), and 2-methyl-3-chloromethylpyridine hydrochloride (0.0356 g, 0.2 mmol, US2005/124586) in acetonitrile (10 mL) was heated at about 60° C., for about 90 h. After cooling to rt the mixture was concentrated in vacuo. The residue was treated with DCM (50 mL) and water (20 mL). The layers were separated and the organic layer was washed with brine, dried (Na2SO4), filtered and concentrated in vacuo. The residue was purified by column chromatography (SiO2, ethyl acetate/methanol 9:1) followed by trituration with diethyl ether to give 1-methyl-4-[2-methyl-4-[(2-methyl-3-pyridyl)methoxy]phenyl]-3-(2-pyridyl)-4,6,7,8-tetrahydropyrazolo[3,4-e][1,4]thiazepine (0.050 g. 0.11 mmol, 50%) as an off white solid: LC-MS (Table 1, Method e) Rt=5.00 min; m/z 458 (M+H)+; 1H-NMR (CDCl3, Bruker 400 MHz) 2.56 (3 H, s) 2.60 (3 H, s) 2.70 (1 H, ddd, J=14.9, 6.1, 2.2 Hz) 2.88 (1 H, ddd, J=14.9, 8.9, 2.6 Hz) 3.19-3.29 (1 H, m) 3.53-3.62 (1 H, m) 3.78 (1 H, br s) 3.84 (3 H, s) 4.97 (2 H, s) 6.63 (1 H, dd, J=8.4, 2.6 Hz) 6.64 (1 H, s) 6.82 (1 H, d, J=2.6 Hz) 7.07 (1 H, ddd, J=7.4, 4.9, 1.1 Hz) 7.11-7.16 (2 H, m) 7.58 (1 H, td, J=7.8, 1.9 Hz) 7.67 (1 H, dd, J=7.7, 1.1 Hz) 7.77 (1 H, dt, J=8.0, 1.0 Hz) 8.45 (1 H, dd, J=4.9, 1.6 Hz) 8.49 (1 H, d, J=4.9 Hz).

Workup

  1. temperatureAfter cooling to rt the mixture
  2. concentrationwas concentrated in vacuo
  3. additionThe residue was treated with DCM (50 mL) and water (20 mL)
  4. customThe layers were separated
  5. washthe organic layer was washed with brine
  6. dry with materialdried (Na2SO4)
  7. filtrationfiltered
  8. concentrationconcentrated in vacuo
  9. customThe residue was purified by column chromatography (SiO2, ethyl acetate/methanol 9:1)

Sources & evidence

ORD record
ord-50eebee74a6448d88b29ad89ca1484e1
Source dataset
uspto-grants-2015_10
Patent number
US09150592B2

Reaction notes

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