Thioglycolic Acid → HCID 136348426, compound

HRID 1748741Notes

Reaction equation

HRID 1748741 reaction equation
[NH2:1][C:2]1[N:6]([CH3:7])[N:5]=[C:4]([C@@H:8]2[CH2:12][CH2:11][CH2:10][N:9]2[C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[CH:3]=1.[C:20](O)(=O)[CH2:21][SH:22].[Cl:25][C:26]1[CH:33]=[C:32]([Cl:34])[CH:31]=[CH:30][C:27]=1[CH:28]=O>>[Cl:25][C:26]1[CH:33]=[C:32]([Cl:34])[CH:31]=[CH:30][C:27]=1[CH:28]1[S:22][CH2:21][CH2:20][NH:1][C:2]2[N:6]([CH3:7])[N:5]=[C:4]([C@@H:8]3[CH2:12][CH2:11][CH2:10][N:9]3[C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[C:3]1=2

Participants

4

Reactant 3

HCID 1133Thioglycolic AcidHCID 134042,4-DichlorobenzaldehydeHCID 86724082HCID 86724082, compound

Product 1

HCID 136348426HCID 136348426, compound

Procedure

tert-Butyl(2S)-2-[4-(2,4-dichlorophenyl)-1-methyl-4,6,7,8-tetrahydropyrazolo[3,4-e][1,4]thiazepin-3-yl]pyrrolidine-1-carboxylate was prepared according to procedure C using tert-butyl (2S)-2-(5-amino-1-methyl-pyrazol-3-yl)pyrrolidine-1-carboxylate, thioglycolic acid and 2,4-dichlorobenzaldehyde. The resulting amide was reduced according to procedure D and the material was used directly in Step D below.

Sources & evidence

ORD record
ord-d67964cd9a2c47ffb86f948353e6099b
Source dataset
uspto-grants-2015_10
Patent number
US09150592B2

Reaction notes

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