Sodium Sulfite → HCID 86688388, compound

Participants

Reaction Steps

To a four-necked flask having a capacity of 1000 mL and equipped with a stirrer, a dropping funnel, and a thermometer, 22.0 g of methyl 7-oxabicyclo[2.2.1]hept-2-ene-5-sulfonate and 450 g of methylene chloride were sequentially added, and the resultant mixture was cooled to 4° C. 22.9 g (0.17 mol) of m-chloroperbenzoic acid was slowly added to the flask under stirring so as to attain a temperature of 10° C. or lower. The resultant mixture was stirred at 5 to 7° C. for 4 hours, and then 100 g of saturated aqueous sodium sulfite solution was added to the mixture, followed by stirring for 30 minutes. The mixture was allowed to stand for liquid-liquid separation, and then washing was carried out thrice with 100 g of saturated aqueous sodium hydrogencarbonate solution. The resultant organic layer was concentrated under reduced pressure, to thereby obtain 20.2 g of methyl 2,3-epoxy-7-oxabicyclo[2.2.1]hept-2-ene-5-sulfonate.

Provenance & Evidence