反应详情

温度

-78 °C

2,8-diphenyldibenzo[b,d]thiophene (6.0) was dissolved in anhydrous tetrahydrofuran (80 mL) under nitrogen atmosphere and the solution was then cooled to −78° C. 20.0 mL of n-butyl lithium (1.6 M solution) was added dropwise into the reaction mixture and continuously stirred to equilibrate to room temperature. The reaction mixture was then cool to −60° C. and trimethyborate (5.67 mL) was added and the reaction was allowed to stir overnight. The reaction was then quenched with 20% aqueous hydrochloric acid, and extracted the organic layer with ethyl acetate; ethyl acetate layer was then washed thoroughly with water and dried over anhydrous sodium sulfate, and was evaporated to dryness to yield 4.5 g of 2,8-diphenyldibenzo[b,d]thiophene-4-boronic acid.

1. customto equilibrate to room temperature
2. temperatureThe reaction mixture was then cool to −60° C.
3. stirringto stir overnight
4. customThe reaction was then quenched with 20% aqueous hydrochloric acid
5. extractionextracted the organic layer with ethyl acetate
6. washethyl acetate layer was then washed thoroughly with water
7. dry with materialdried over anhydrous sodium sulfate
8. customwas evaporated to dryness