Hydrochloric Acid → HCID 70980027, compound

HRID 1749088Notes

Reaction equation

C(O[C:6](=O)[N:7](C)[C@H:8]([C:10](=[O:24])[NH:11][C:12]1[CH:13]=[CH:14][C:15]2[NH:20][C:19](=[O:21])[C@H:18]([CH3:22])[NH:17][C:16]=2[N:23]=1)[CH3:9])(C)(C)C.[ClH:27]>>[ClH:27].[CH3:6][NH:7][C@@H:8]([CH3:9])[C:10]([NH:11][C:12]1[CH:13]=[CH:14][C:15]2[NH:20][C:19](=[O:21])[C@H:18]([CH3:22])[NH:17][C:16]=2[N:23]=1)=[O:24]

Participants

Reactant 2

HCID 313Hydrochloric Acid2×

HCID 70980412HCID 70980412, compound

Product 1

HCID 70980027HCID 70980027, compound

Procedure

Methyl-[(S)-1-((S)-3-methyl-2-oxo-1,2,3,4-tetrahydro-pyrido[2,3-b]pyrazin-6-ylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester (30 mg, 0.08 mmol) was treated with HCl according to the General procedure 3 (HCl deprotection) to afford the title compound (15 mg). 1H NMR (400 MHz, Me-d3-OD): 7.25 (1H, d), 6.91 (1H, d), 4.43-4.32 (1H, m), 4.12 (1H, d), 2.79 (3H, s), 1.67 (3H, d), 1.53 (3H, d). MS: [M+H]+=264.

Sources & evidence

ORD record: ord-d3a90c22a331417097ce94b7e566ba0c
Source dataset: uspto-grants-2015_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09155743B2

Reaction notes

Loading…