Hydrochloric Acid → HCID 70980222, compound

HRID 1749102Notes

Reaction equation

C(O[C:6](=O)[N:7](C)[C@H:8]([C:10](=[O:35])[NH:11][C:12]1[CH:13]=[CH:14][C:15]2[N:16]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[C:17](=[O:28])[N:18]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH2:19][C:20]=2[N:21]=1)[CH3:9])(C)(C)C.[ClH:38]>>[ClH:38].[CH3:6][NH:7][C@@H:8]([CH3:9])[C:10]([NH:11][C:12]1[CH:13]=[CH:14][C:15]2[N:16]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[C:17](=[O:28])[N:18]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH2:19][C:20]=2[N:21]=1)=[O:35]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 70981791HCID 70981791, compound

Product 1

HCID 70980222HCID 70980222, compound

Procedure

Methyl-[(S)-1-(2-oxo-1,3-diphenyl-1,2,3,4-tetrahydro-pyrido[3,2-d]pyrimidin-6-ylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester (35 mg, 0.07 mmol) was treated with HCl according to the General procedure 3 to afford the title compound (28 mg). 1H NMR (400 MHz, Me-d3-OD): 7.91 (1H, d), 7.64-7.38 (9H, m), 7.38-7.28 (1H, m), 6.70 (1H, d), 5.03 (2H, s), 4.01 (1H, q), 2.74 (3H, s), 1.62 (3H, d). MS: [M+H]+=402.

Sources & evidence

ORD record: ord-c5e56f7ec4e045a39d720b425f939987
Source dataset: uspto-grants-2015_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09155743B2

Reaction notes

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