N,N-Dimethylglycine → HCID 18723056, compound

HRID 1749114Notes

Reaction equation

HRID 1749114 reaction equation
[CH3:1][N:2]([CH3:7])[CH2:3][C:4](O)=[O:5].[CH2:8]([NH2:10])[CH3:9]>>[CH3:1][N:2]([CH3:7])[CH2:3][C:4]([NH:10][CH2:8][CH3:9])=[O:5]

Participants

3

Reactant 2

HCID 673N,N-DimethylglycineHCID 6341Ethylamine

Product 1

HCID 18723056HCID 18723056, compoundYield 94.9%

Procedure

N,N-dimethylglycine (0.8 g, 6.8 mmol) was dissolved in an aqueous solution of 70% ethylamine (5.7 g, 68 mmol), and the solution was placed in a closed vessel and stored at 5° C. for 3 days. The solution was concentrated under reduced pressure, and the resultant oily product was subjected to column chromatography, followed by extraction with a chloroform/methanol mixed solvent, to thereby obtain Exemplified Compound (6) (0.84 g, 94.4%) as a colorless oil.

Workup

  1. customthe solution was placed in a closed vessel
  2. concentrationThe solution was concentrated under reduced pressure
  3. extractionfollowed by extraction with a chloroform/methanol mixed solvent

Sources & evidence

ORD record
ord-d3c9f0549e174cca8d560cd334b9beaf
Source dataset
uspto-grants-2015_10
Patent number
US09155914B2

Reaction notes

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