反应详情

温度

45 °C

Aqueous 1 N sodium hydroxide solution (225 μl, 0.225 mmol) was added to an ethanol (1.7 ml) solution of ethyl 2-{4-cyano-7-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]-5-methyl-6-phenyl-1,3-benzoxazol-2-yl}-1,3-thiazole-4-carboxylate (I-198) (87.0 mg, 0.173 mmol), followed by stirring in an oil bath at 45° C. for 1 hour. With cooling with ice, 1 N hydrochloric acid (225 μl, 0.225 mmol) was added to the reaction liquid, followed by concentration, under reduced pressure, and the obtained pale yellow solid was purified in slurry with a mixed solvent of ethanol:water=9:1 to obtain the entitled compound (50.0 mg, 59.7%) as a pale yellow solid.

1. additionwas added to the reaction liquid
2. concentrationfollowed by concentration, under reduced pressure
3. customthe obtained pale yellow solid was purified in slurry with a mixed solvent of ethanol