反应详情

温度

110 °C

A mixture of Compound 135 (60 mg), 2M dimethylamine/tetrahydrofuran solution (766 μL), potassium iodide (2.82 mg), triethylamine (23.7 μL) and n-butanol (1.0 mL) was stirred at 110° C. for 2 days in a sealed tube. Subsequently, the reaction mixture was concentrated under reduced pressure and the resulting residue was purified by silica gel column chromatography (ethyl acetate:hexane=1:3 to 99:1) to give 12.1 mg (19% yield) of the desired product as a pale yellow amorphous.

1. concentrationSubsequently, the reaction mixture was concentrated under reduced pressure
2. customthe resulting residue was purified by silica gel column chromatography (ethyl acetate:hexane=1:3 to 99:1)