HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Amino-3,5-dimethylisoxazole → 4-Bromo-2,6-dichloro-N-(3,5-dimethyl-isoxazol-4-yl)-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Amino-3,5-dimethylisoxazole | HCID 182040 | — |
| Reactant | 4-Bromo-2,6-dichlorobenzene-1-sulfonyl chloride | HCID 2737466 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 4-Bromo-2,6-dichloro-N-(3,5-dimethyl-isoxazol-4-yl)-benzenesulfonamide | HCID 67184343 | 49% |
Reaction Steps
Prepared from 4-bromo-2,6-dichlorobenzenesulfonyl chloride (1.00 g, 3.19 mmol) and 4-amino-3,5-dimethylisoxazole (0.346 g, 3.1 mmol) in pyridine (6 ml) according to the method of intermediate 1, to give the title compound as a tan solid (606 mg, 1.51 mmol, 49%). δH (CDCl3, 300K) 7.70 (2H, s), 6.66 (1H, s), 2.23 (3H, s), 2.05 (3H, s). m/z (ES+, 70V) 400.9 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09156811B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-c777829978e64d26820217bfe95f2f9f |
| Source note | uspto-grants-2015_10 |