Ammonium Hydroxide → HCID 82418513, compound

HRID 1749429Notes

Reaction equation

HRID 1749429 reaction equation
[CH2:1]([C:3]1[C:8]([C:9]#[N:10])=[CH:7][N:6]=[CH:5][N:4]=1)[CH3:2].[OH-].[NH4+]>CO.[Ni]>[CH2:1]([C:3]1[C:8]([CH2:9][NH2:10])=[CH:7][N:6]=[CH:5][N:4]=1)[CH3:2]

Participants

5

Reactant 2

HCID 14923Ammonium HydroxideHCID 82651084HCID 82651084, compound

Product 1

HCID 82418513HCID 82418513, compoundYield 59%

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

To the solution of 4-ethylpyrimidine-5-carbonitrile (1.0 equiv.) in MeOH (0.4 M) was added ammonium hydroxide and Raney nickel. The mixture was stirred at room temperature under hydrogen atmosphere overnight and then the reaction mixture was filtered through celite. The filtrate was concentrated in vacuum to give the crude title compound (59%), which was used for the next step without further purification. MS (ESI) m/z 138.1/[M+H]+.

Workup

  1. filtrationthe reaction mixture was filtered through celite
  2. concentrationThe filtrate was concentrated in vacuum

Sources & evidence

ORD record
ord-638e7634279c43a3bd3f821e5ff06c25
Source dataset
uspto-grants-2015_10
Patent number
US09156798B2

Reaction notes

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