Trifluoroacetic acid → HCID 118162120, compound

HRID 1749449Notes

Reaction equation

HRID 1749449 reaction equation
[OH:1][C:2]1([CH3:18])[CH2:7][CH2:6][C@@H:5]([NH:8]C(=O)OC(C)(C)C)[CH2:4][C:3]1([CH3:17])[CH3:16].C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:8][C@@H:5]1[CH2:6][CH2:7][C:2]([CH3:18])([OH:1])[C:3]([CH3:17])([CH3:16])[CH2:4]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 131733583HCID 131733583, compound

Product 1

HCID 118162120HCID 118162120, compoundYield 133.1%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of tert-butyl ((1R)-4-hydroxy-3,3,4-trimethylcyclohexyl)carbamate (520 mg, 2.15 mmol) in DCM (6.00 mL) was added TFA (3.00 mL) at 0° C. The result mixture was stirred at room temperature for 1 h. The reaction was concentrated in vacuo to give a crude product (450 mg, crude), which was used directly for next step without further purification. MS (ESI) m/z 158.1 [M+H]+.

Workup

  1. concentrationThe reaction was concentrated in vacuo

Sources & evidence

ORD record
ord-8146ed559ceb4578994ec5b0a3b58164
Source dataset
uspto-grants-2015_10
Patent number
US09156798B2

Reaction notes

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