反应详情

温度

100 °C

A mixture of N-[2-(5-chloro-2-sulfamoyl-phenyl)-ethyl]-acetamide (209 mg, 0.76 mmol) and potassium hydroxide aqueous solution (2 mol/L, 3 mL, 6 mmol) was stirred at 100° C. for 4 h. After cooling to room temperature, the reaction was neutralized with 2N of aqueous hydrochloric acid solution. The mixture was concentrated to dryness and the residue was diluted with solvent (3% MeOH in DCM, 200 mL) and stirred for 1 h. The mixture was filtered and the filtrate was concentrated to afford the title compound as a gray solid (150 mg, 0.64 mmol, 85% yield). MS (ESI) m/z 235.1, 237.1 [M+H]+.

1. temperatureAfter cooling to room temperature
2. concentrationThe mixture was concentrated to dryness
3. additionthe residue was diluted with solvent (3% MeOH in DCM, 200 mL)
4. stirringstirred for 1 h
5. filtrationThe mixture was filtered
6. concentrationthe filtrate was concentrated