Trifluoroacetic acid → HCID 118162233, compound

HRID 1749518Notes

Reaction equation

HRID 1749518 reaction equation
[OH:1][C:2]1([CH3:17])[CH2:16][C:4]2([CH2:7][CH:6]([NH:8]C(=O)OC(C)(C)C)[CH2:5]2)[CH2:3]1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:8][CH:6]1[CH2:7][C:4]2([CH2:16][C:2]([CH3:17])([OH:1])[CH2:3]2)[CH2:5]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 131733592HCID 131733592, compound

Product 1

HCID 118162233HCID 118162233, compoundYield 112.4%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of tert-butyl (6-hydroxy-6-methylspiro[3.3]heptan-2-yl)carbamate (760 mg, crude) in DCM (7 mL) was added TFA (3.5 mL) at ˜0° C. to 5° C. The resulting reaction mixture was stirred at room temperature for 1 h. The reaction mixture was concentrated to give the crude product (500 mg, crude) as a brown oil, which was used in the next step without further purification. MS (ESI) m/z 142.1 [M+H]+.

Workup

  1. customThe resulting reaction mixture
  2. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-714eb49e965b4e3c9e3bdcc43712e936
Source dataset
uspto-grants-2015_10
Patent number
US09156798B2

Reaction notes

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