HCID 131733594, compound → HCID 118162113, compound

HRID 1749549Notes

Reaction equation

HRID 1749549 reaction equation
[C:1]([C@H:4]1[CH2:7][C@@H:6]([NH:8]C(=O)OCC2C=CC=CC=2)[C:5]1([CH3:20])[CH3:19])(=[O:3])[NH2:2]>[Pd].CO>[NH2:8][C@@H:6]1[CH2:7][C@H:4]([C:1]([NH2:2])=[O:3])[C:5]1([CH3:20])[CH3:19]

Participants

4

Reactant 1

HCID 131733594HCID 131733594, compound

Product 1

HCID 118162113HCID 118162113, compoundYield 120.6%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Conditions

Temperature
25 °C

Procedure

A mixture of benzyl ((1R,3S)-3-carbamoyl-2,2-dimethylcyclobutyl)carbamate (193 mg, 0.70 mmol) and palladium on activated carbon (10% Pd, 30 mg) in MeOH (5 mL) was stirred at 25° C. under hydrogen atmosphere for 5 h. The reaction mixture was filtered through celite and the filtrate was concentrated to afford the crude title compound (120 mg, crude). MS (ESI) m/z 143.1 [M+H]+.

Workup

  1. filtrationThe reaction mixture was filtered through celite
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-2360b4730ab048eba0315a789e9d5b45
Source dataset
uspto-grants-2015_10
Patent number
US09156798B2

Reaction notes

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