反应详情

A solution of tert-butyl (Z)-4-({2-[(7-{[tert-butoxycarbonyl(methyl)-amino]methyl}-1H-indol-3-yl)methylene]-6-hydroxy-3-oxo-2,3-dihydrobenzofuran-7-yl}methyl)piperazine-1-carboxylate (0.044 g, 0.071 mmol) in methylene chloride (2.0 mL) was added with a 4 M solution of hydrogen chloride in 1,4-dioxane (2.0 mL), and then the mixture was stirred at room temperature for 4 hours. The mixture was azeotroped twice with toluene under reduced pressure, and then the residual solid was suspended in a mixed solvent of chloroform and methanol and thereby washed to obtain (Z)-6-hydroxy-2-({7-[(methylamino)methyl]-1H-indol-3-yl}methylene)-7-(piperazin-1-ylmethyl)benzofuran-3(2H)-one trihydrochloride (0.025 g, 72%).

1. customThe mixture was azeotroped twice with toluene under reduced pressure
2. washwashed