反应详情

温度

60 °C

A solution of 6-hydroxy-7-(morpholinomethyl)benzofuran-3(2H)-one (0.125 g, 0.500 mmol) in methanol (2 mL) was added with 1H-indazole-3-carbaldehyde (0.0731 g, 0.500 mmol), and piperidine (0.00426 g, 0.0500 mmol) at room temperature, and the mixture was stirred at 60° C. for 2 hours. The reaction mixture was cooled to room temperature, and then the precipitated solid was collected by filtration to obtain (Z)-2-[(1H-indazol-3-yl)methylene]-6-hydroxy-7-(morpholinomethyl)benzofuran-3(2H)-one (0.119 g, 63%).

1. temperatureThe reaction mixture was cooled to room temperature
2. filtrationthe precipitated solid was collected by filtration