反应详情

温度

60 °C

A solution of tert-butyl 4-[3-(6-methoxy-3-oxo-2,3-dihydrobenzofuran-7-yl)propyl]piperazine-1-carboxylate (0.0642 g, 0.164 mmol) in methanol (3 mL) was added with 1H-indazole-3-carboxaldehyde (0.0264 g, 0.180 mmol) and piperidine (0.0112 g, 0.131 mmol), and the mixture was stirred at 60° C. for 2 hours. The reaction mixture was concentrated, and then the residue was purified by silica gel column chromatography (chloroform/methanol) to obtain tert-butyl (Z)-4-(3-{2-[(1H-indazol-3-yl)methylene]-6-methoxy-3-oxo-2,3-dihydrobenzofuran-7-yl}propyl)piperazine-1-carboxylate (0.0393 g, 46%).

1. concentrationThe reaction mixture was concentrated
2. customthe residue was purified by silica gel column chromatography (chloroform/methanol)