反应详情

温度

60 °C

A solution of tert-butyl 4-[4-(6-methoxy-3-oxo-2,3-dihydrobenzofuran-7-yl)butyl]piperazine-1-carboxylate (0.0860 g, 0.212 mmol) in methanol (5 mL) was added with 1H-indazole-3-carboxaldehyde (0.0282 g, 0.193 mmol) and piperidine (7 drops), and the mixture was stirred at 60° C. for 2 hours. The reaction mixture was concentrated, and then the residue was purified by silica gel column chromatography (chloroform/methanol) to obtain tert-butyl (Z)-4-(4-{2-[(1H-indazol-3-yl)methylene]-6-methoxy-3-oxo-2,3-dihydrobenzofuran-7-yl}butyl)piperazine-1-carboxylate (0.0945 g, 91%).

1. concentrationThe reaction mixture was concentrated
2. customthe residue was purified by silica gel column chromatography (chloroform/methanol)