反应详情

温度

60 °C

A solution of tert-butyl 4-[(6-methoxy-3-oxo-2,3-dihydrobenzofuran-7-yl)ethynyl]piperidine-1-carboxylate (0.103 g, 0.277 mmol) in methanol (5 mL) was added with 1H-indazole-3-carboxaldehyde (0.0386 g, 0.264 mmol) and piperidine (7 drops), and the mixture was stirred at 60° C. for 2 hours. The reaction mixture was concentrated, and the resulting residue was purified by silica gel column chromatography (chloroform/methanol) to obtain tert-butyl (Z)-4-({2-[(1H-indazol-3-yl)methylene]-6-methoxy-3-oxo-2,3-dihydrobenzofuran-7-yl}ethynyl)piperidine-1-carboxylate (0.105 g, 80%).

1. concentrationThe reaction mixture was concentrated
2. customthe resulting residue was purified by silica gel column chromatography (chloroform/methanol)