反应详情

温度

60 °C

A solution of tert-butyl 4-[2-(6-methoxy-3-oxo-2,3-dihydrobenzofuran-7-yl)ethyl]piperidine-1-carboxylate (0.0542 g, 0.144 mmol) in methanol (3 mL) was added with 1H-indazole-3-carboxaldehyde (0.0211 g, 0.144 mmol) and piperidine (5 drops), and the mixture was stirred at 60° C. for 2 hours. The reaction mixture was concentrated, and the resulting residue was purified by silica gel column chromatography (chloroform/methanol) to obtain tert-butyl (Z)-4-(2-{2-[(1H-indazol-3-yl)methylene]-6-methoxy-3-oxo-2,3-dihydrobenzofuran-7-yl}ethyl)piperidine-1-carboxylate (0.0524 g, 72%).

1. concentrationThe reaction mixture was concentrated
2. customthe resulting residue was purified by silica gel column chromatography (chloroform/methanol)