反应详情

A mixture of intermediate 19 (196 mg, 1.2 mmol), 1,4-dibromobutane (0.43 mL, 3.6 mmol) and anhydrous K2CO3 (166 mg, 1.22 mmol) was dissolved in EtOH (4 mL) and the solution was heated to reflux and stirred overnight. The mixture was diluted with water and extracted with EtOAc. The combined EtOAc layers were washed with water, brine, dried over anhydrous Na2SO4, concentrated in vacuo and purified by flash chromatography on silica gel column (elution with PE/EtOAc=3:1) to give 7-(4-bromobutoxy)-3,4-dihydroisoquinolin-1(2H)-one (intermediate 21) (230 mg, 63%) as a white solid.

1. temperaturethe solution was heated
2. temperatureto reflux
3. extractionextracted with EtOAc
4. washThe combined EtOAc layers were washed with water, brine
5. dry with materialdried over anhydrous Na2SO4
6. concentrationconcentrated in vacuo
7. custompurified by flash chromatography on silica gel column (elution with PE/EtOAc=3:1)