HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-(2-methoxyphenyl)-1,4-diazepane HCl
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tert-butyl 4-(2-methoxyphenyl)-1,4-diazepane-1-carboxylate | HCID 66631820 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 1-(2-methoxyphenyl)-1,4-diazepane HCl | HCID 19095564 | 64% |
Reaction Steps
Excess HCl in EtOAc was added dropwise to a solution of intermediate 28 (396 mg, 1.29 mmol) in EtOAc and the reaction mixture was stirred at rt for 1.5 h. Filtration gave 1-(2-methoxyphenyl)-1,4-diazepane hydrochloride (intermediate 29) (200 mg, 64%) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09156822B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-1478769cf76142c987f8b135e5bc79b3 |
| Source note | uspto-grants-2015_10 |