反应详情

Excess HCl in EtOAc was added dropwise to a solution of intermediate 28 (396 mg, 1.29 mmol) in EtOAc and the reaction mixture was stirred at rt for 1.5 h. Filtration gave 1-(2-methoxyphenyl)-1,4-diazepane hydrochloride (intermediate 29) (200 mg, 64%) as a white solid.

1. filtrationFiltration