HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen iodide → 6-hydroxy-1H-indazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen iodide | HCID 24841 | — |
| Reactant | 6-Methoxy-1H-indazole | HCID 12639202 | — |
| Product | 6-hydroxy-1H-indazole | HCID 135483987 | 86% |
Reaction Steps
A mixture of 6-methoxy-1H-indazole (560 mg, 3.8 mmol) and HI (2.4 mL 48%) was heated to reflux for 4 h. The mixture was extracted with CH2Cl2. The combined organic layers were washed with water, brine, concentrated in vacuo, and purified by column chromatography (CH2Cl2/MeOH=60/1) to give 1H-indazol-6-ol (intermediate 43) (436 mg, 86%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09156822B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-bce95d5fbb24486a961c4d7923b9ac97 |
| Source note | uspto-grants-2015_10 |