Hydrochloric Acid → (S)-2-Amino-4-methyl-pentane-1-sulfonic acid methylamide-hydrochloride

HRID 1750184Notes

Reaction equation

HRID 1750184 reaction equation
C(OC(=O)[NH:7][C@H:8]([CH2:13][S:14](=[O:18])(=[O:17])[NH:15][CH3:16])[CH2:9][CH:10]([CH3:12])[CH3:11])(C)(C)C.[ClH:20]>O1CCOCC1>[ClH:20].[CH3:16][NH:15][S:14]([CH2:13][C@@H:8]([NH2:7])[CH2:9][CH:10]([CH3:11])[CH3:12])(=[O:17])=[O:18]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86714402((S)-3-Methyl-1-methylsulfamoylmethyl-butyl)-carbamic acid tert-butyl ester

Product 1

HCID 86714400(S)-2-Amino-4-methyl-pentane-1-sulfonic acid methylamide-hydrochlorideYield 100%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

105 mg of ((S)-3-Methyl-1-methylsulfamoylmethyl-butyl)-carbamic acid tert-butyl ester were dissolved in 2 ml of dioxane and reacted with 1.3 ml of 4M hydrochloric acid in dioxane at it for 16 h. The reaction was concentrated in vacuo and the resulting crude product was used without further purification. 60 mg (100%) of (S)-2-Amino-4-methyl-pentane-1-sulfonic acid methylamide-hydrochloride were obtained.

Workup

  1. concentrationThe reaction was concentrated in vacuo
  2. customthe resulting crude product was used without further purification

Sources & evidence

ORD record
ord-b74da5948bf1434dae962c804cfef3db
Source dataset
uspto-grants-2015_10
Patent number
US09156796B2

Reaction notes

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