化工社化工社 化学情報印刷レポート · 研究参考用
Dimethylformamide → 4-(1-Ethyl-propylamino)-3-nitro-benzoic acid methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 3-Pentanamine | HCID 12019 | — |
| 反応物 | Methyl 4-fluoro-3-nitrobenzoate | HCID 5219721 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 4-(1-Ethyl-propylamino)-3-nitro-benzoic acid methyl ester | HCID 85998571 | 97.4% |
反応手順
To a solution of 5.38 g of 4-fluoro-3-nitro-benzoic acid methyl ester in 25 ml of abs. DMF was added 5.60 g of potassium carbonate, followed by 2.67 g of 3-aminopentane. After 3 h at rt, the mixture was poured into water, and extracted with ethyl acetate three times. The combined organic phases were washed with water, dried over sodium sulphate and concentrated to yield 7.01 g (97%) of 4-(1-Ethyl-propylamino)-3-nitro-benzoic acid methyl ester as a light brown oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09156796B2 |
| 出典データセット | uspto-grants-2015_10 |
| ORD ID | ord-28cab29705574f309b5b540fffd17716 |
| 出典メモ | uspto-grants-2015_10 |