反应详情

To a solution of 5.38 g of 4-fluoro-3-nitro-benzoic acid methyl ester in 25 ml of abs. DMF was added 5.60 g of potassium carbonate, followed by 2.67 g of 3-aminopentane. After 3 h at rt, the mixture was poured into water, and extracted with ethyl acetate three times. The combined organic phases were washed with water, dried over sodium sulphate and concentrated to yield 7.01 g (97%) of 4-(1-Ethyl-propylamino)-3-nitro-benzoic acid methyl ester as a light brown oil.

1. extractionextracted with ethyl acetate three times
2. washThe combined organic phases were washed with water
3. dry with materialdried over sodium sulphate
4. concentrationconcentrated