反应详情

4.70 g of 4-(1-Ethyl-propylamino)-3-(2-furan-2-yl-acetylamino)-benzoic acid methyl ester were dissolved in 25 ml of dry dioxane and 50 ml of 4M hydrochloric acid in dioxane were added. The reaction was heated to reflux for 10 h and concentrated to yield 4.70 g (100%) of 1-(1-Ethyl-propyl)-2-furan-2-ylmethyl-1H-benzoimidazole-5-carboxylic acid methyl ester which was used in the next step without further purification.

1. temperatureThe reaction was heated
2. temperatureto reflux for 10 h
3. concentrationconcentrated