反应详情

A solution of 348 mg of 1-(1-ethyl-propyl)-2-furan-2-ylmethyl-1H-benzoimidazole-5-carboxylic acid in 5 ml of ethanol was hydrogenated at 5 bar for 24 h in the presence of 10 mg platinum oxide. The catalyst was removed by filtration, and the filtrate was concentrated in vacuo. The resulting residue was purified by HPLC to obtain 55 mg (17%) of 1-(1-Ethyl-propyl)-2-(tetrahydro-furan-2-ylmethyl)-1H-benzoimidazole-5-carboxylic acid.

1. customThe catalyst was removed by filtration
2. concentrationthe filtrate was concentrated in vacuo
3. customThe resulting residue was purified by HPLC