Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1750206Generated: October 31, 2026

1-(1-Ethyl-propyl)-2-furan-2-ylmethyl-1H-benzoimidazole-5-carboxylic acid → 1-(1-Ethyl-propyl)-2-(tetrahydro-furan-2-ylmethyl)-1H-benzoimidazole-5-carboxylic acid

https://huagongshe.com/reaction/1750206

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(1-Ethyl-propyl)-2-furan-2-ylmethyl-1H-benzoimidazole-5-carboxylic acidHCID 86714417—
CatalystPlatinum oxide (PtO)HCID 82844—
SolventEthanolHCID 702—
Product1-(1-Ethyl-propyl)-2-(tetrahydro-furan-2-ylmethyl)-1H-benzoimidazole-5-carboxylic acidHCID 8671437517%

Reaction Steps

A solution of 348 mg of 1-(1-ethyl-propyl)-2-furan-2-ylmethyl-1H-benzoimidazole-5-carboxylic acid in 5 ml of ethanol was hydrogenated at 5 bar for 24 h in the presence of 10 mg platinum oxide. The catalyst was removed by filtration, and the filtrate was concentrated in vacuo. The resulting residue was purified by HPLC to obtain 55 mg (17%) of 1-(1-Ethyl-propyl)-2-(tetrahydro-furan-2-ylmethyl)-1H-benzoimidazole-5-carboxylic acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09156796B2
Source datasetuspto-grants-2015_10
ORD IDord-0810db3c636c4a0a95930f0de9041e61
Source noteuspto-grants-2015_10