反应详情

0.99 g 3-[2-(5-Chloro-thiophen-2-yl)-acetylamino]-4-(1-ethyl-propylamino)-benzoic acid methyl ester were reacted with 10 ml of 4M hydrochloric acid in dioxane in a microwave reactor at 130° C. for 15 min. The reaction was concentrated. The residue was dissolved in ethyl actate, washed with saturated aqueous sodium bicarbonate solution and brine, dried over sodium sulphate and concentrated to yield 0.73 g (77%) of 2-(5-Chloro-thiophen-2-ylmethyl)-1-(1-ethyl-propyl)-1H-benzoimidazole-5-carboxylic acid methyl ester.

1. concentrationThe reaction was concentrated
2. dissolutionThe residue was dissolved in ethyl actate
3. washwashed with saturated aqueous sodium bicarbonate solution and brine
4. dry with materialdried over sodium sulphate
5. concentrationconcentrated