反应详情

温度

130 °C

To 2.16 g of 4-(1-Ethyl-propylamino)-3-(2-thiazol-5-yl-acetylamino)-benzoic acid methyl ester were added 15 ml of 4M hydrochloric acid in dioxane. The reaction was divided in three portions and each was heated at 130° C. in a microwave reactor for 15 min. 2 ml of water were added to each vial and the reaction mixtures were heated to 140° C. for 15 min. The combined reaction mixtures were concentrated and the residue purified by chromatography (silica, ethyl acetate/heptane) to yield 1.50 g (77%) of 1-(1-Ethyl-propyl)-2-thiazol-5-ylmethyl-1H-benzoimidazole-5-carboxylic acid.

1. customthe reaction mixtures
2. temperaturewere heated to 140° C. for 15 min
3. customThe combined reaction mixtures
4. concentrationwere concentrated
5. customthe residue purified by chromatography (silica, ethyl acetate/heptane)