反应详情

温度

135 °C

0.77 g 4-(2-Methyl-cyclohexylamino)-3-(2-thiophen-2-yl-acetylamino)-benzoic acid methyl ester were reacted with 5 ml of 4M hydrochloric acid in dioxane at 100° C. in a microwave reactor for 5 min. 1 ml water was added and the mixture was heated to 135° C. for 15 min. The reaction was concentrated and the residue purified by chromatography (silica, ethyl acetate/heptane) to yield 0.65 g (91%) of 1-((1R,2R)-2-Methyl-cyclohexyl)-2-thiophen-2-ylmethyl-1H-benzoimidazole-5-carboxylic acid.

1. concentrationThe reaction was concentrated
2. customthe residue purified by chromatography (silica, ethyl acetate/heptane)