HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-(2-Methyl-cyclopentyl)-2-thiophen-2-ylmethyl-1H-benzoimidazole-5-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-(2-Methyl-cyclopentylamino)-3-(2-thiophen-2-yl-acetylamino)-benzoic acid methyl ester | HCID 86714453 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 1-(2-Methyl-cyclopentyl)-2-thiophen-2-ylmethyl-1H-benzoimidazole-5-carboxylic acid | HCID 86714454 | 121.8% |
Reaction Steps
0.88 g 4-(2-Methyl-cyclopentylamino)-3-(2-thiophen-2-yl-acetylamino)-benzoic acid methyl ester were reacted with 10 ml of 4M hydrochloric acid in dioxane at 110° C. in a microwave reactor for 30 min. The reaction was concentrated and 0.98 g (99%) of 1-(2-Methyl-cyclopentyl)-2-thiophen-2-ylmethyl-1H-benzoimidazole-5-carboxylic acid were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09156796B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-4ba59956c7e24985abaec511265a3e0f |
| Source note | uspto-grants-2015_10 |