反应详情

0.88 g 4-(2-Methyl-cyclopentylamino)-3-(2-thiophen-2-yl-acetylamino)-benzoic acid methyl ester were reacted with 10 ml of 4M hydrochloric acid in dioxane at 110° C. in a microwave reactor for 30 min. The reaction was concentrated and 0.98 g (99%) of 1-(2-Methyl-cyclopentyl)-2-thiophen-2-ylmethyl-1H-benzoimidazole-5-carboxylic acid were obtained.

1. concentrationThe reaction was concentrated