反应详情

温度

130 °C

0.59 g 4-(2-Ethyl-cyclohexylamino)-3-(2-thiophen-2-yl-acetylamino)-benzoic acid methyl ester were reacted with 10 ml of 4M hydrochloric acid in dioxane at 130° C. in a microwave reactor for 20 min. 1 ml water was added and the mixture was heated to 130° C. for 30 min. The reaction was concentrated and the residue purified by chromatography (silica, ethyl acetate/heptane) to yield 0.47 g (88%) of 1-(2-Ethyl-cyclohexyl)-2-thiophen-2-ylmethyl-1H-benzoimidazole-5-carboxylic acid.

1. concentrationThe reaction was concentrated
2. customthe residue purified by chromatography (silica, ethyl acetate/heptane)