4-Chloro-5-iodo-2-methyl-7H-pyrrolo[2,3-d]pyrimidine → HCID 86706959, compound

HRID 1750287Notes

Reaction equation

HRID 1750287 reaction equation
[Cl:1][C:2]1[C:3]2[C:11]([I:12])=[CH:10][NH:9][C:4]=2[N:5]=[C:6]([CH3:8])[N:7]=1.ClC1C2C(I)=CN([CH2:24][O:25][CH2:26][CH2:27][Si:28]([CH3:31])([CH3:30])[CH3:29])C=2N=CN=1>>[Cl:1][C:2]1[C:3]2[C:11]([I:12])=[CH:10][N:9]([CH2:24][O:25][CH2:26][CH2:27][Si:28]([CH3:31])([CH3:30])[CH3:29])[C:4]=2[N:5]=[C:6]([CH3:8])[N:7]=1

Participants

3

Reactant 2

HCID 665707094-Chloro-5-iodo-2-methyl-7H-pyrrolo[2,3-d]pyrimidineHCID 867069334-chloro-5-iodo-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine

Product 1

HCID 86706959HCID 86706959, compound

Procedure

4-Chloro-5-iodo-2-methyl-7H-pyrrolo[2,3-d]pyrimidine (C22) was converted to the product according to the method used for synthesis of 4-chloro-5-iodo-7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidine (C1) in Preparation P1. The product was obtained as a yellow oil. Yield: 400 mg, 0.94 mmol, 84%. LCMS m/z 424.0[M+H+].

Workup

  1. customThe product was obtained as a yellow oil

Sources & evidence

ORD record
ord-d060b66585354704a103925a9dcc7ce5
Source dataset
uspto-grants-2015_10
Patent number
US09156845B2

Reaction notes

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