反应详情

A mixed solution of 2-(2-(1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl)thiazol-4-yl)acetic acid (95 mg, 0.19 mmol) and 1N aqueous sodium hydroxide solution (0.286 mL, 0.29 mmol) in ethanol (2 mL) and THF (2 mL) was stirred at room temperature for 3 hr. The reaction mixture was concentrated under reduced pressure, and water and 1N hydrochloric acid were added to the residue. After extraction with ethyl acetate, washing with water and saturated brine and drying, the solvent was evaporated under reduced pressure to give the title compound (74 mg, 0.157 mmol, 83%) as a white powder.

1. concentrationThe reaction mixture was concentrated under reduced pressure, and water and 1N hydrochloric acid
2. additionwere added to the residue
3. extractionAfter extraction with ethyl acetate
4. washwashing with water and saturated brine
5. customdrying
6. customthe solvent was evaporated under reduced pressure