4-Aminotetrahydropyran → HCID 86721210, compound

HRID 1750371Notes

Reaction equation

HRID 1750371 reaction equation
[C:1]([N:5]1[C:9]([C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)=[C:8]([C:17]2[S:18][CH:19]=[C:20]([CH2:22][C:23]([OH:25])=O)[N:21]=2)[CH:7]=[N:6]1)([CH3:4])([CH3:3])[CH3:2].[NH2:26][CH:27]1[CH2:32][CH2:31][O:30][CH2:29][CH2:28]1>>[C:1]([N:5]1[C:9]([C:10]2[CH:11]=[CH:12][C:13]([F:16])=[CH:14][CH:15]=2)=[C:8]([C:17]2[S:18][CH:19]=[C:20]([CH2:22][C:23]([NH:26][CH:27]3[CH2:32][CH2:31][O:30][CH2:29][CH2:28]3)=[O:25])[N:21]=2)[CH:7]=[N:6]1)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 4192234-AminotetrahydropyranHCID 867211822-(2-(1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl)thiazol-4-yl)acetic acid

Product 1

HCID 86721210HCID 86721210, compound

Procedure

Using 2-(2-(1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl)thiazol-4-yl)acetic acid and 4-aminotetrahydropyran and by reaction and purification in the same manner as in the method described in Example 1, step 7, the title compound was obtained.

Workup

  1. customby reaction and purification in the same manner as in the method

Sources & evidence

ORD record
ord-9b292ee872ca42aaa78fcacd10d0baf3
Source dataset
uspto-grants-2015_10
Patent number
US09156837B2

Reaction notes

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