Hydrogen chloride-ethyl acetate → HCID 86721211, compound

HRID 1750372Notes

Reaction equation

HRID 1750372 reaction equation
[C:1]([N:5]1[C:9]([C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)=[C:8]([C:17]2[S:18][CH:19]=[C:20]([CH:22]3[CH2:27][CH2:26][N:25](C(O)=O)[CH2:24][CH2:23]3)[N:21]=2)[CH:7]=[N:6]1)([CH3:4])([CH3:3])[CH3:2].[ClH:31].C(OCC)(=O)C>C(OCC)(=O)C>[ClH:31].[C:1]([N:5]1[C:9]([C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)=[C:8]([C:17]2[S:18][CH:19]=[C:20]([CH:22]3[CH2:23][CH2:24][NH:25][CH2:26][CH2:27]3)[N:21]=2)[CH:7]=[N:6]1)([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 86721213HCID 86721213, compound

Product 1

HCID 86721211HCID 86721211, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a solution of 4-(2-(1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl)thiazol-4-yl)piperidine-1-carboxylic acid (338 mg, 0.70 mmol) in ethyl acetate (1 mL) was added 4N hydrogen chloride/ethyl acetate (1 mL, 4.00 mmol), and the mixture was stirred at room temperature for 14 hr. The precipitate was collected by filtration, and washed with ethyl acetate to give the title compound (294 mg, 0.698 mmol, 100%) as a pale-yellow powder.

Workup

  1. filtrationThe precipitate was collected by filtration
  2. washwashed with ethyl acetate

Sources & evidence

ORD record
ord-62efe44210344c9690fd5f8401f4e3d6
Source dataset
uspto-grants-2015_10
Patent number
US09156837B2

Reaction notes

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