4-Cyanobenzoic acid → HCID 86721216, compound

HRID 1750375Notes

Reaction equation

HRID 1750375 reaction equation
Cl.[C:2]([N:6]1[C:10]([C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)=[C:9]([C:18]2[S:19][CH:20]=[C:21]([CH:23]3[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]3)[N:22]=2)[CH:8]=[N:7]1)([CH3:5])([CH3:4])[CH3:3].[C:29]([C:31]1[CH:39]=[CH:38][C:34]([C:35](O)=[O:36])=[CH:33][CH:32]=1)#[N:30]>>[C:2]([N:6]1[C:10]([C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)=[C:9]([C:18]2[S:19][CH:20]=[C:21]([CH:23]3[CH2:24][CH2:25][N:26]([C:35]([C:34]4[CH:38]=[CH:39][C:31]([C:29]#[N:30])=[CH:32][CH:33]=4)=[O:36])[CH2:27][CH2:28]3)[N:22]=2)[CH:8]=[N:7]1)([CH3:5])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 120874-Cyanobenzoic acidHCID 86721211HCID 86721211, compound

Product 1

HCID 86721216HCID 86721216, compound

Procedure

Using 4-{2-[1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl]-1,3-thiazol-4-yl}piperidine monohydrochloride and 4-cyanobenzoic acid and by reaction and purification in the same manner as in the method described in Example 1, step 7, the title compound was obtained.

Workup

  1. customby reaction and purification in the same manner as in the method

Sources & evidence

ORD record
ord-57eecebce40d4abca0be35817e426352
Source dataset
uspto-grants-2015_10
Patent number
US09156837B2

Reaction notes

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