反应详情

Methanamine (40% aq, 1 ml, 11.55 mmol) was added to a solution of 2-(2-{[4-(trifluoromethyl)pyridin-2-yl]methyl}cyclopentyl)-2,3-dihydro-1H-isoindole-1,3-dione (0.100 g, 0.27 mmol) in ethanol (6 ml) in a microwave vial. The vial was sealed and stirred at room temperature for 18 hours and then heated to 60° C. for 5 hours. The reaction was cooled to room temperature and concentrated in vacuo. This was then purified by SCX chromatography (2M ammonia in methanol) to afford the title compound.

1. customThe vial was sealed
2. temperatureheated to 60° C. for 5 hours
3. temperatureThe reaction was cooled to room temperature
4. concentrationconcentrated in vacuo
5. customThis was then purified by SCX chromatography (2M ammonia in methanol)