反应详情

温度

60 °C

To a solution of tert-butyl N-[(1S,2S)-2-(dibenzylamino)cyclopentyl]carbamate (320 mg, 0.841 mmol) in THF (2.8 ml) at room temperature was added drop wise lithium aluminium hydride in THF (1 M, 1.3 ml, 1.261 mmol). The reaction was stirred for 1 hour and then was heated to 60° C. for 3 hours. The reaction was then cooled to room temperature and quenched by the addition of sodium sulfate decahydrate, filtered and washed with THF and ethyl acetate. The filtrate was concentrated in vacuo to afford the title compound.

1. temperatureThe reaction was then cooled to room temperature
2. customquenched by the addition of sodium sulfate decahydrate
3. filtrationfiltered
4. washwashed with THF and ethyl acetate
5. concentrationThe filtrate was concentrated in vacuo