反应详情

To a solution of 1-methyl-6-(4-methylbenzenesulfonyl)-6-azabicyclo[3.1.0]hexane (55 g, 219.12 mmol) in IPA (1000 ml) and water (1000 ml) was added sodium azide (57.0 g, 876.92 mmol). The reaction mixture was stirred at room temperature for 17 hours. The reaction was cooled to room temperature and water (1000 ml) was added. The aqueous layer was extracted with diethyl ether (3×500 ml). The combined organics were washed with brine (250 ml), dried over sodium sulfate, concentrated in vacuo to afford the title compound.

1. temperatureThe reaction was cooled to room temperature
2. extractionThe aqueous layer was extracted with diethyl ether (3×500 ml)
3. washThe combined organics were washed with brine (250 ml)
4. dry with materialdried over sodium sulfate
5. concentrationconcentrated in vacuo