反应详情

A solution of tert-butyl N-[(1S,2S)-2-aminocyclopentyl]carbamate (CAS number 586961-34-4; 1 g, 4.99 mmol), 2-chloro-5-(trifluoromethyl)pyrazine (CAS number 799557-87-2; 1.09 g, 5.99 mmol) and DIPEA (2.62 ml, 14.98 mmol) in DMSO (17 ml) was subjected to microwave irradiation at 140° C. for 1 hour. The reaction was partitioned between ethyl acetate and water, washed with water, brine, dried over magnesium sulfate and concentrated in vacuo. The resulting residue was purified by column chromatography (silica, 0-100% ethyl acetate/petrol) to afford the title compound.

1. customirradiation at 140° C. for 1 hour
2. customThe reaction was partitioned between ethyl acetate and water
3. washwashed with water, brine
4. dry with materialdried over magnesium sulfate
5. concentrationconcentrated in vacuo
6. customThe resulting residue was purified by column chromatography (silica, 0-100% ethyl acetate/petrol)