Water → 2-(Bromomethyl)-5-(trifluoromethyl)pyridine
Reaktionsgleichung
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:4]=[CH:5][C:6]([CH2:9]O)=[N:7][CH:8]=1.[Br:13]P(Br)Br.O>C(Cl)Cl>[Br:13][CH2:9][C:6]1[CH:5]=[CH:4][C:3]([C:2]([F:12])([F:11])[F:1])=[CH:8][N:7]=1Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
To a solution of [5-(trifluoromethyl)pyridin-2-yl]methanol (5.0 g, 28.24 mmol) in DCM (50 ml) was added tribromophosphane (0.58 g, 3.50 mmol) at 0° C. The reaction was allowed to warm to room temperature and stirred for 3 hours. The reaction was then poured into water (50 ml) and the organics were extracted with DCM (2×50 ml), washed with brine, dried over sodium sulfate and concentrated in vacuo to afford the title compound which was used without further purification.
Aufarbeitung
- extractionthe organics were extracted with DCM (2×50 ml)
- washwashed with brine
- dry with materialdried over sodium sulfate
- concentrationconcentrated in vacuo
Quellen und Nachweise
- ORD-Eintrag
- ord-344aefc510244ed6833bc00683a8e2d6
- Quelldatensatz
- uspto-grants-2015_10
- Patentnummer
- US09156829B2
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